智能生物学实验室（IBLab）
Institute of Medical Genetics and Genomics, Fudan University. Research Building 2, No. 131 Dong'an Road, Xuhui District, Shanghai, China. yuanbo@ion.ac.cn · 021-54231035.
Intelligent Biology Laboratory (IBLab)
Research Building 2, No. 131 Dong'an Road
Xuhui District, Shanghai, China 200032
yuanbo@ion.ac.cn · 021-54231035
Dr. Bo Yuan is a Junior Principal Investigator and Supervisor of Master’s Students at the Institute of Medical Genetics and Genomics, Fudan University. He received his B.S. in Biological Sciences from Zhejiang University in 2010 and his Ph.D. in Neurobiology from the University of Chinese Academy of Sciences in 2017 (advisor: Dr. Zilong Qiu). After graduation, he stayed at the Institute of Neuroscience, Chinese Academy of Sciences (now Center for Excellence in Brain Science and Intelligence Technology), serving as Assistant Investigator, Associate Investigator, and Director of the High-Performance Computing Cluster. In October 2024, he joined Fudan University and established the Intelligent Biology Laboratory.
Dr. Yuan focuses on the genetic mechanisms and precision interventions of neurodevelopmental disorders such as autism spectrum disorder. Along the research chain of “genetic discovery — tool innovation — in vivo validation,” he has accumulated continuous expertise in population genetics, molecular mechanisms, gene-editing tool development, and disease modeling. He has published papers as first or co-first author in Molecular Psychiatry, Nature Communications, Nucleic Acids Research, Neuroscience Bulletin, and other journals, and has led projects funded by the National Natural Science Foundation of China and the Shanghai Natural Science Foundation.
The Intelligent Biology Laboratory (IBLab) is affiliated with the Institute of Medical Genetics and Genomics, Fudan University. We focus on the genetic basis, pathogenic mechanisms, and precision intervention strategies of neurodevelopmental disorders such as autism spectrum disorder. By integrating population genetics, genomics, brain organoids and assembloids, gene editing, and artificial intelligence, we aim to build a continuous evidence chain from risk-gene identification to intervention-parameter optimization.
Our research directions include:
- Pathogenic mechanisms and intervention strategies of neuropsychiatric candidate genes in the Chinese population;
- Human developmental models based on iPSC-derived brain organoids and assembloids;
- AI- and structure-guided optimization of gene-editing tools, especially base editors;
- High-performance computing and multi-omics data integration methods.
The lab leverages the platforms of Fudan University’s Medical Research Data Center and CFFF High-Performance Computing Platform to enable interdisciplinary “wet-and-dry” research.
We are recruiting motivated students and collaborators. If you are interested in joining us, please contact Dr. Yuan at yuanbo@ion.ac.cn.
news
| Dec 31, 2025 | Commentary “Re-examining interneuron-specific Nrp2 deletion: overlooked striatal and cortical contributions” was published in Molecular Psychiatry. |
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| Dec 31, 2024 | Collaborative paper “Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins” was published in Nature Communications. |
| Dec 14, 2024 | The laboratory joined the National Key R&D Program key special project on reproductive health and women and children’s health as a core participant. |
| Nov 30, 2024 | The laboratory was awarded a Shanghai Natural Science Foundation General Program grant on mitochondrial dysfunction candidate genes in the Chinese autism cohort. |
| Sep 30, 2024 | Dr. Bo Yuan joined the Institute of Medical Genetics and Genomics, Fudan University, and established the Intelligent Biology Laboratory (IBLab). |
latest posts
| Mar 26, 2025 | a post with plotly.js |
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| Dec 04, 2024 | a post with image galleries |
| May 01, 2024 | a post with tabs |