CV
Curriculum vitae of Dr. Bo Yuan, Principal Investigator of the Intelligent Biology Laboratory.
Contact Information
| Name | Bo Yuan |
| Professional Title | Junior Principal Investigator · Supervisor of Master's Students |
| yuanbo@ion.ac.cn | |
| Location | 1st Floor, Building B, No. 2 Medical Research Building, 138 Yixueyuan Road, Shanghai, Xuhui |
Professional Summary
Junior Principal Investigator and Supervisor of Master’s Students at the Institute of Medical Genetics and Genomics, Fudan University. Research interests include neurodevelopmental disorder genetics, base editing, high-throughput sequencing, and computational biology. Victoria Concordia Crescit.
Experience
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2024 - Present Shanghai, China
Junior Principal Investigator & Supervisor of Master's Students
Institute of Medical Genetics and Genomics, Fudan University
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2022 - 2024 Shanghai, China
Associate Investigator & Director of High-Performance Computing Cluster & Graduate Student Counselor
Center for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences
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2021 - 2022 Shanghai, China
Assistant Investigator & Director of High-Performance Computing Cluster & Graduate Student Counselor
Center for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences
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2020 - 2021 Shanghai, China
Assistant Investigator & Graduate Student Counselor
Center for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences
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2017 - 2020 Shanghai, China
Assistant Investigator
Institute of Neuroscience, Chinese Academy of Sciences
Education
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2010 - 2017 Shanghai, China
Ph.D.
Institute of Neuroscience, Chinese Academy of Sciences
Neurobiology
- Advisor: Dr. Zilong Qiu
- Recognized as an Outstanding Student at the University of Chinese Academy of Sciences.
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2006 - 2010 Hangzhou, Zhejiang, China
B.S.
College of Life Sciences, Zhejiang University
Biological Sciences
- Advisor: Dr. Yunpeng Zhao
- Awarded the National Scholarship.
- Awarded Outstanding Graduate of Zhejiang University.
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2003 - 2006 Qingdao, Shandong, China
High School Diploma
Qingdao No.2 Middle School of Shandong Province
High School Diploma
- Advisor: Mr. Shaopeng Fa
- Got First Place in the Shandong division of the National High School Biology Olympiad, awarded to the highest scorers in the province.
Skills
Molecular Biology (Advanced): DNA/RNA extraction, PCR, gel electrophoresis, Western blot, cell culture, immunofluorescence
Neuroscience (Advanced): Microscopy, mouse handling, stereotaxic surgery, animal behavior analysis
DevOps (Advanced): Hardware provisioning, Slurm, Cromwell, Nextflow, AWS, Docker, Singularity
Programming (Advanced): Shell, Python, R, LaTeX
Music Proficiency (Piano Grade 10): Piano
Languages
Chinese : Native speaker
English : Professional proficiency
Publications
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2025 Re-examining interneuron-specific Nrp2 deletion: overlooked striatal and cortical contributions
Molecular Psychiatry
Accepted.
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2025 Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins
Nature Communications
Accepted.
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2025 Whole-brain in vivo base editing reverses behavioral changes in Mef2c-mutant mice
Nature Neuroscience
27: 116-128.
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2023 Identification of de novo mutations in the Chinese ASD cohort via whole-exome sequencing unveils brain regions implicated in autism
Neuroscience Bulletin
39(10): 1469-1480.
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2023 Engineering of cytosine base editors with genotoxicity minimization and editing scope diversification
Nucleic Acids Research
51(20): e105.
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2023 TadA orthologs enable both cytosine and adenine editing of base editors
Nature Communications
14: 414.
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2023 TadA reprogramming to generate potent miniature base editors with high precision
Nature Communications
14: 413.
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2022 Novel IL1RAP mutation associated with schizophrenia interferes with neuronal growth and related NF-κB signal pathways
Neuroscience Letters
775.
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2022 Identification of CHMP4C as a new risk gene for inherited dilated cardiomyopathy
Journal of Genetics and Genomics
49: 169-172.
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2021 An intronic variant of CHD7 identified in autism patients interferes with neuronal differentiation and development
Neuroscience Bulletin
37(8): 1091-1106.
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2020 Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice
Science Bulletin
65(14).
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2020 Reversal of social recognition deficit in adult mice with MECP2 duplication via normalization of MeCP2 in the medial prefrontal cortex
Neuroscience Bulletin
36(6): 570-584.
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2020 Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
Nature Communications
11: 5827.
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2019 Expanding C-T base editing toolkit with diversified cytidine deaminases
Nature Communications
10: 3612.
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2019 Towards the framework of understanding autism spectrum disorders
Neuroscience Bulletin
35(6): 1110-1112.
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2017 Mir505-3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12
Autophagy
13(10): 1679-1696.
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2017 Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome
Scientific Reports
7: 41701.
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2017 Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors
Journal of Genetics and Genomics
44(1): 63-66.
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2016 Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs
Scientific Reports
6: 20392.
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2015 Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress
Scientific Reports
5: 7645.
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2012 NeuroD2 regulates the development of hippocampal mossy fiber synapses
Neural Development
7: 9.