Genetic dissection of the Chinese ASD cohort
Integrate genomic, single-cell transcriptomic, and brain imaging data from a large Chinese autism cohort to localize key brain regions and pathways.
Based on whole-exome sequencing of a large Chinese ASD cohort, we integrate genomic, single-cell transcriptomic, and brain imaging data to localize key brain regions and pathways.
Research aims
- Discover and annotate rare de novo and inherited variants in the Chinese ASD cohort.
- Integrate genomic data with single-cell brain atlases and neuroimaging.
- Identify convergent pathways and cell types affected by risk genes.
- Provide a data foundation for genetic diagnosis and mechanism studies.