work Pathogenic windows and rescue thresholds Define developmental windows and minimum repair thresholds for ASD risk mutations using isogenic iPSC-derived brain organoids and assembloids. AI-assisted base editor development Leverage Fudan’s CFFF high-performance computing platform to develop next-generation precision base editors with AI large language models and structural prediction. Genetic dissection of the Chinese ASD cohort Integrate genomic, single-cell transcriptomic, and brain imaging data from a large Chinese autism cohort to localize key brain regions and pathways. fun HPC platform and bioinformatics methods Build and optimize high-performance computing and PB-scale storage platforms for genomics, imaging, and AI, and develop high-throughput sequencing analysis pipelines.
